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Updated: Jun 7, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Profiling oxidative stress markers and cardiovascular complications in chronic kidney disease patients supplemented
Leila Azouaou1,2,3, Mounir Adnane2,4, Omar Chabati2,5
1Nephrology Service, Hussein Dey Hospital, Algiers, Algeria.
Insights
Vitamin E supplementation did not reduce cardiovascular complications in chronic kidney disease (CKD) patients. This study highlights the need for new antioxidant strategies for CKD patients experiencing oxidative stress.
Area of Science:
- Nephrology
- Cardiology
- Biochemistry
Background:
- Cardiovascular diseases (CVD) are frequent in chronic kidney disease (CKD).
- Oxidative stress, linked to renal and metabolic issues, contributes to CVD in hemodialysis patients.
- Understanding oxidative stress markers is crucial for managing CVD in CKD.
Purpose of the Study:
- To analyze oxidative stress markers in CKD patients receiving antioxidant and vitamin E supplementation.
- To monitor cardiovascular complications (CVC) in CKD patients undergoing vitamin E treatment.
Main Methods:
- A cross-sectional study involving 99 CKD patients.
- Oral vitamin E (300 mg/day) supplementation for 2 years.
- Measurement of oxidative stress markers: nitric oxide (NO), myeloperoxidase (MPO), oxidized low-density lipoprotein (LDLox), malondialdehyde (MDA), and glutathione before and after treatment.
Main Results:
- CKD patients with CVC showed higher levels of NO, LDLox, MDA, and MPO, and lower glutathione compared to those without CVC.
- After 2 years of vitamin E treatment, no significant reduction in overall cardiovascular complications was observed.
- Specific marker levels pre- and post-treatment were detailed, indicating limited impact of vitamin E on these markers.
Conclusions:
- Oral vitamin E supplementation did not significantly alter the occurrence of cardiovascular complications in CKD patients.
- The findings suggest that current vitamin E supplementation strategies may not be sufficient for mitigating CVC in CKD.
- Further research is needed to explore novel antioxidant supplementation approaches for CKD patients.
Introduction:
Cardiovascular diseases are common complications in chronic kidney disease (CKD). Oxidative stress associated with renal and metabolic dysfunctions is one of the cardiovascular complications (CVC) in haemodialysis patients. The aim of the present study is to analyse the oxidative stress markers in CDK patients supplemented with antioxidants and vitamin E, with monitoring of CVC.
Material And Methods:
This was a cross-sectional study conducted on 99 subjects. CKD patients received oral supplementation of vitamin E (300 mg/day) for 2 years. Oxidative stress markers, nitric oxide (NO); myeloperoxidase (MPO); oxidized low-density lipoprotein (LDLox); malondialdehyde (MDA) and glutathione were measured before and after the vitamin treatment.
Results:
NO (62.62 ±2.80 μmol/l), LDLox (10.55 ±4.62 μmol/l), MDA (6.11 ±2.83 μmol/l) and MPO (53.35 ±3.82 UI/ml) were overconcentrated, while glutathione (62.09 ±4.15 UI/ml) was less concentrated in CKD patients with cardiovascular complications, compared to those without cardiovascular complications (67.08 ±1.90 μmol/l, 31.18 ±5.25 μmol/l, 16 ±6.47 μmol/l, 57.00 ±7.24 UI/ml, 43.09 ±3.33 UI/ml, respectively). After 2 years of vitamin E treatment, the overall cardiovascular complications were not significantly decreased.
Conclusions:
These results showed that oral complementation with vitamin E did not affect the occurrence of cardiovascular complications associated with CKD. These findings may pave the way for future innovative strategies for antioxidant supplementation in CKD patients.
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