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ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysis

Jiawei He1, Meili Duan1, Haizhou Zhuang1

  • 1Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Heliyon
|November 19, 2024
PubMed

Insights

Elevated levels of intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1) are linked to increased risks of sepsis, septic shock, and mortality. This systematic review highlights their role in sepsis pathogenesis.

Area of Science:

  • Biomedical Science
  • Clinical Medicine
  • Pathophysiology

Background:

  • Endothelial cell dysfunction and microcirculatory disturbances are key in sepsis development.
  • Intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1) are critical endothelial proteins implicated in sepsis.

Purpose of the Study:

  • To systematically review and meta-analyze the association between plasma levels of ICAM1 and VCAM1 and clinical outcomes in sepsis patients.
  • To explore the relationship of ICAM1 and VCAM1 with sepsis, septic shock, and multiple-organ dysfunction syndrome (MODS).

Main Methods:

  • Searched MEDLINE and EMBASE databases up to November 28, 2023.
  • Evaluated ICAM1 and VCAM1 plasma levels and patient outcomes using standardized mean differences (SMDs) with 95% confidence intervals (CIs).
  • Included 41 studies in the meta-analysis.

Main Results:

  • Both ICAM1 and VCAM1 were significantly associated with sepsis.
  • Elevated ICAM1 and VCAM1 levels correlated with MODS and septic shock.
  • Higher ICAM1 and VCAM1 levels were associated with increased overall and sepsis-related mortality.

Conclusions:

  • Elevated plasma ICAM1 and VCAM1 levels are associated with higher risks of sepsis, septic shock, MODS, and mortality.
  • These findings underscore the role of endothelial adhesion molecules in sepsis progression and outcomes.
Abstract

Keywords:
ICAM1MODSMortalitySepsisSeptic shockVCAM1

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