Relative peripheral refractive errors in Chinese children with myopic anisometropia
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Updated: Jun 7, 2025
Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
Published on: March 29, 2022
Yu-Ting Tong1,2,3, Yu-Qin Du1,4, Shan-Shan Ge1,4
1Eye School of Chengdu University of Traditional Chinese Medicine (TCM), Chengdu 610036, Sichuan Province, China.
Insights
In Chinese children with myopic anisometropia (MAI), more myopic eyes exhibit greater hyperopic relative peripheral refractive errors (RPRE). These RPRE variations are linked to differences in spherical equivalent refraction and axial length.
Area of Science:
- Ophthalmology
- Optometry
- Pediatric Eye Care
Background:
- Myopic anisometropia (MAI) is a common condition in children, characterized by significant differences in refractive error between the eyes.
- Understanding peripheral refractive error (RPRE) patterns is crucial for myopia progression research and management.
Purpose of the Study:
- To compare RPRE in Chinese children with and without MAI.
- To investigate the relationship between RPRE and myopia progression indicators.
Main Methods:
- An observational, cross-sectional study involving 160 children, categorized into MAI (interocular spherical equivalent refraction difference ≥1.0 D) and non-MAI groups.
- Multispectral refraction topography was used to measure various RPRE parameters, alongside standard ocular biometrics like axial length (AL).
Main Results:
- Significant interocular differences in RPRE parameters were observed in the MAI group, particularly in total refraction difference value (TRDV) and specific peripheral zones (RDV-S, RDV-I, RDV-T, RDV-N).
- Subgroup analysis revealed differences based on the magnitude of interocular spherical equivalent refraction (∆SER) difference.
- Correlation analysis showed that changes in RPRE (∆RPRE) were negatively correlated with ∆SER and positively correlated with ∆AL.
Conclusions:
- Chinese children with MAI demonstrate larger hyperopic RPRE in more myopic eyes within specific retinal ranges.
- Partial RPRE variations are significantly associated with differences in spherical equivalent refraction and axial length, suggesting a role in myopia development.
Aim:
To compare relative peripheral refractive errors (RPREs) in Chinese children with and without myopic anisometropia (MAI) and to explore the relationship between RPRE and myopia.
Methods:
This observational cross-sectional study included 160 children divided into two groups according to the interocular spherical equivalent refraction (SER) difference ≥1.0 D in the MAI group (n=80) and <1.0 D in the non-MAI group (n=80). The MAI group was further divided into two subgroups: ∆SER<2.0 D group and ∆SER≥2.0 D group. Basic ocular biometric parameters of axial length (AL), average keratometry (Ave K), cylinder (CYL), surface regularity index (SRI), and surface asymmetry index (SAI) were recorded. In addition, multispectral refraction topography was performed to measure RPRE, and the parameters were recorded as total refraction difference value (TRDV), refraction difference value (RDV) 0-10, RDV10-20, RDV20-30, RDV30-40, RDV40-53, RDV-superior (RDV-S), RDV-inferior (RDV-I), RDV-temporal (RDV-T) and RDV-nasal (RDV-N).
Results:
In the non-MAI group, the interocular differences of all parameters of RPRE were not significant. In the MAI group, the interocular differences of TRDV, RDV10-53, RDV-S, RDV-I, RDV-T, and RDV-N were significant. In subgroup analysis, the interocular differences of TRDV, RDV30-53, RDV-I, and RDV-T were significant in ∆SER<2.0 D group and ∆SER≥2.0 D group, but the interocular differences of RDV10-30, RDV-S and RDV-N were only significant in the ∆SER≥2.0 D group. In correlation analysis, ∆TRDV, ∆RDV 10-53, ∆RDV-S, and ∆RDV-N were negatively correlated with ∆SER but positively correlated with ∆AL.
Conclusion:
The more myopic eyes have larger hyperopic RPRE in Chinese children with MAI in certain retinal range, and partial ∆RPRE is closely associated with ∆SER and ∆AL.
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