Young Women and Myocardial Infarction: Unveiling Clinical Patterns and Prognostic Outcomes

Background Myocardial infarction (MI) remains a critical emergency with an increasing incidence among young women exposed to various risk factors. Despite extensive data on MI, there is limited information on premature coronary artery disease in women under the age of 50 years. This study describes the clinical, paraclinical, and angiographic characteristics of MI in young women compared to older women and determines the prognosis. Methods This is a single-center retrospective study including women hospitalized between July 2019 and December 2021 in the cardiology department for the evaluation of MI. The population was divided into two groups based on age: women under 50 years, classified as young women, and those aged 50 years and above. A comparison was made between these two groups. Results A total of 197 women were included in our study. Forty-four women under 50 and 153 over 50 years were included. The mean age of young women was 44 ± 6 years. The main cardiovascular (CV) risk factors in young women were smoking (46%), hypertension (53%), diabetes (44%), and family history of coronary artery disease (21%). Autoimmune disease was present in 11%. Of the young women, 34% were admitted for ST-elevation myocardial infarction (STEMI), with 47% consulting late (>12 hours). The majority (91%) presented with typical chest pain. Monovessel disease was observed in 57% of young women. The left anterior descending artery was the most affected at 55%. Atherosclerosis was the most noted etiology (66%), followed by spontaneous coronary artery dissection (SCAD) (16%). The comparative study showed that young women had fewer overall CV risk factors but a higher prevalence of smoking, familial history of coronary artery disease, and autoimmune disease. Young women presented more frequently with non-ST elevation myocardial infarction (NSTEMI). Monovessel disease was more common, and they required less myocardial revascularization by percutaneous intervention. Young women presented more with SCAD and less with atherosclerotic MI. The in-hospital follow-up showed that young women experienced fewer major cardiac and cerebrovascular events (MACCE) compared to older women, with no in-hospital deaths recorded among young women. Long-term follow-up revealed a lower incidence of MACCE among young women (11% vs. 32.7% in older women) and a similar low mortality rate. Survival analysis showed that young women had a longer event-free survival time for MACCE (91.3 months) compared to older women (65.5 months). Conclusions The incidence of MI in young women is increasing. Smoking and hypertension are major risk factors. Hospital complications are rare, and prognosis is generally good, with low mortality rates.