Related Experiment Video
Updated: Aug 18, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Abstract:
Kienbock's disease (lunate malacia) is an unusual but not rare cause of wrist pain. It is manifested by avascular necrosis and subsequent disintegration of the lunate. Despite recognition of this disease entity for the past 70 years, its cause is still debated. Most investigators relate it to a stress fracture that leads to devascularization of the major segment of the lunate if the lunate is supplied by one volar vessel. The classification of Kienbock's disease is based on its roentgenologic appearance. Stage 1 consists of small fracture lines. Stage 2 is rarification along the fracture line, usually on the volar pole. Stage 3 shows sclerosis of the bone dorsal to the fracture site. Stage 4 shows sclerosis of the bone dorsal to the fracture site, and collapse and secondary fracture with loss of architectural integrity of the lunate. Stage 5 shows secondary arthritic changes of the radius. Treatment is categorized into two general types. The first is an attempt to allow revascularization of the lunate be relieving the compression forces. This is accomplished by lengthening the ulna and/or shortening the radius, with capitate-hamate fusion; or by shortening the capitate and fusing the capitate and hamate. These procedures are performed in the early stages of Kienbock's disease. The second type of treatment, used in more advanced cases, includes excision of the lunate: replacement of the lunate by prosthesis, with or without capitate shortening and/or capitate-hamate fusion; and various types of intercarpal fusion.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Cryptococcal Meningitis

