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Hyperhomocysteinemia prevalence among patients with venous thromboembolism

R Ben Salah1, M Boudaya2, S Fendri2

  • 1Department of internal medicine, Faculty of Medicine, University of SFAX, Sfax, Tunisia.

Future Science OA
|November 19, 2024
PubMed

Insights

Elevated plasma homocysteine (Hcy) levels and hyperhomocysteinemia (HHC) are significantly more prevalent in Tunisian deep vein thrombosis (DVT) patients compared to healthy individuals. This suggests HHC is a risk factor for DVT.

Area of Science:

  • Cardiovascular Research
  • Clinical Biochemistry
  • Thrombosis and Hemostasis

Background:

  • Hyperhomocysteinemia (HHC), characterized by elevated plasma homocysteine (Hcy) levels, is increasingly recognized as a potential risk factor for venous thromboembolism.
  • Deep Vein Thrombosis (DVT) is a significant health concern, and understanding its associated risk factors is crucial for effective prevention and management.

Purpose of the Study:

  • To investigate plasma homocysteine levels and the prevalence of hyperhomocysteinemia in Tunisian patients diagnosed with deep vein thrombosis.
  • To compare these findings with a control group of healthy individuals to establish a potential association between HHC and DVT in this population.

Main Methods:

  • An observational case-control study was conducted.
  • Plasma homocysteine (Hcy) levels were measured in hospitalized patients with unprovoked DVT and compared to healthy controls.
  • Levels of vitamin B12 and B9 were also determined, given their role in homocysteine metabolism.

Main Results:

  • Mean plasma homocysteine levels were significantly higher in DVT patients compared to controls.
  • The prevalence of hyperhomocysteinemia was markedly elevated in DVT patients (61.7%) versus controls (4%).
  • Hyperhomocysteinemia was associated with a 3.54-fold increased risk of developing DVT.

Conclusions:

  • This study demonstrates a strong association between elevated homocysteine levels and deep vein thrombosis in the studied Tunisian population.
  • Hyperhomocysteinemia is a prevalent condition and a significant risk factor for DVT.
Abstract

Keywords:
Hyperhomocysteinemiadeep vein thrombosishomocysteine levelsprevalence

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