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A resurfaced sensor NLR confers new recognition specificity to non-MAX effectors
Tongtong Zhu1,2, Xuefeng Wu1,2, Guixin Yuan1,3
1The State Key Laboratory of Maize Bio-breeding, Joint International Research Laboratory of Crop Molecular Breeding, Ministry of Agriculture Key Laboratory for Crop Pest Monitoring and Green Control, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Abstract:
Replacing the HMA domain of the rice (Oryza sativa) immune receptor RGA5 with that of the rice HMA DOMAIN-CONTAINING PROTEIN 120 (HMA120) creates a designer RGA5HMA120 that confers resistance to Magnaporthe oryzae isolates expressing the non-MAX effector gene AVR-Pita, thus enabling the generation of new synthetic resistance genes.
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