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Exploring the causal relationships between type 2 diabetes and neurological disorders using a Mendelian randomization
Yongfang Wei1,2, Shuling Xu3, Zhaoquan Wu1,2
1School of Pharmaceutical Science, Changsha Medical University, Changsha, China.
Medicine
|November 19, 2024
Summary
Type 2 diabetes (T2D) is linked to an increased risk of several neurological disorders. This study used Mendelian randomization to confirm a causal relationship between T2D and conditions like carpal tunnel syndrome.
Area of Science:
- Neuroscience
- Endocrinology
- Genetics
Background:
- Growing evidence links diabetes to neurological conditions.
- The causal relationship between type 2 diabetes (T2D) and specific neurological disorders remains underexplored.
Purpose of the Study:
- To investigate the causal effects of T2D on 67 neurological diseases using a Mendelian randomization (MR) approach.
- To identify specific neurological conditions causally associated with T2D.
Main Methods:
- Employed Mendelian randomization (MR) with inverse-variance weighted, weighted median, and MR-Egger methods.
- Utilized MR-PRESSO for outlier detection and correction.
- Assessed heterogeneity using Cochrane Q-values.
Main Results:
- Identified a suggestive association between T2D and an increased risk of 8 neurological diseases (P < .05).
- Confirmed causal links for nerve, nerve root, and plexus disorders (OR=1.11), neurological diseases (OR=1.05), and carpal tunnel syndrome (OR=1.10) after FDR correction.
Conclusions:
- The study affirms a cause-and-effect association between type 2 diabetes and specific neurological disorders.
- Findings highlight the importance of managing T2D to potentially mitigate neurological disease risk.
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