Related Experiment Video

Updated: Jun 7, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

49.7K

Pediatric MASLD: current understanding and practical approach

Anne-Sophie R Stroes1, Miriam Vos2, Marc A Benninga1

  • 1Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

European Journal of Pediatrics
|November 19, 2024
PubMed

Insights

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing concern in children, linked to obesity. New criteria and emerging treatments highlight the importance of early identification and management of this liver condition.

Area of Science:

  • Pediatric Gastroenterology and Hepatology
  • Metabolic Disorders
  • Public Health

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading chronic liver disease in children globally, driven by increasing obesity rates.
  • MASLD is associated with significant risks, including progressive liver damage, type 2 diabetes mellitus, and cardiovascular disease.
  • Current challenges include underdiagnosis due to low awareness and the absence of straightforward diagnostic criteria.

Purpose of the Study:

  • To review the epidemiology and risk factors of pediatric MASLD.
  • To provide an evidence-based approach for screening, diagnosis, and treatment of MASLD in children.
  • To highlight recent advancements in diagnostic criteria and emerging therapeutic options.

Main Methods:

  • Literature review of current evidence and expert opinion on pediatric MASLD.
  • Analysis of epidemiological data and risk factors.
  • Synthesis of updated diagnostic guidelines and treatment strategies.

Main Results:

  • MASLD is strongly associated with childhood obesity, overweight, and insulin resistance.
  • New diagnostic criteria simplify the identification of MASLD, shifting it from a diagnosis of exclusion to a positive diagnosis.
  • Emerging effective treatments for adults suggest potential future therapies for children.

Conclusions:

  • Early identification of pediatric MASLD is crucial, especially with new diagnostic tools and potential treatments on the horizon.
  • A proactive approach to screening, diagnosis, and management is needed to address the rising prevalence of MASLD.
  • Further research is warranted to optimize treatment strategies for children with MASLD.

Keywords:
ChildrenMASHMASLDObesity

More Related Videos

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

786
Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties12:55

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties

Published on: September 27, 2020

8.4K

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
67
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
131