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Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

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Published on: February 10, 2012

Current and Emerging Approaches to Imaging Large Vessel Vasculitis.

Ahmed Tawakol¹, Brittany Nicole Weber², Michael T Osborne¹

¹Cardiology Division and the Cardiovascular Imaging Research Center (A.T., M.T.O., H.C.L.), Massachusetts General Hospital and Harvard Medical School, Boston.

Circulation. Cardiovascular Imaging

|November 19, 2024

Summary

Large vessel vasculitides (LVV), including giant cell arteritis and Takayasu arteritis, are inflammatory artery diseases. Noninvasive imaging is now essential for diagnosing LVV and monitoring arterial damage.

Keywords:

Computed tomography Takayasu arteritis aorta giant cell arteritis magnetic resonance imaging positron-emission tomography

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Last Updated: Jun 7, 2025

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

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Published on: February 10, 2012

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Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

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Published on: October 25, 2024

Area of Science:

Rheumatology
Cardiovascular Medicine
Radiology

Background:

Large vessel vasculitides (LVV) are inflammatory conditions affecting major arteries like the aorta.
Giant cell arteritis (GCA) and Takayasu arteritis (TA) are primary forms of LVV.
Untreated LVV can cause severe complications such as blindness, stenosis, and aneurysms.

Purpose of the Study:

To review the current applications of noninvasive vascular imaging in the diagnosis and management of LVV.
To highlight the role of imaging in reducing the need for invasive procedures like temporal artery biopsy in GCA.
To discuss the utility of imaging in monitoring disease activity and treatment response in LVV.

Main Methods:

Review of current literature on noninvasive vascular imaging techniques in LVV.
Discussion of imaging modalities including ultrasound, MRI, CT, and PET.
Analysis of imaging's role in diagnosis, surveillance, and assessment of disease activity.

Main Results:

Noninvasive imaging has transformed LVV management, enabling prompt diagnosis.
Imaging techniques like ultrasound, MRI, CT, and PET are routinely used for LVV diagnosis.
Vascular imaging aids in longitudinal surveillance and is being investigated for assessing treatment response and vascular remodeling.

Conclusions:

Noninvasive vascular imaging is indispensable in the modern management of large vessel vasculitides.
Imaging facilitates early detection, reduces reliance on invasive methods, and aids in long-term patient monitoring.
Ongoing research focuses on imaging's potential to evaluate treatment efficacy and vascular changes in LVV.