Decatungstate-Photocatalyzed Hydroamidomethylation of Azobenzenes with N,N-Dimethylamides
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Updated: Jun 7, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Jingya Yang1, Cunhui Wang1, Yating Han1
1College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, People's Republic of China.
Abstract:
A photocatalytic hydroamidomethylation of azobenzenes with N,N-dimethylamides has been developed. Using tetrabutylammonium decatungstate (TBADT) as a photocatalyst, an array of azobenzenes and N,N-dimethylamides reacted smoothly under visible light irradiation, affording previously unreported N-amidomethyl-N,N'-diarylhydrazines in generally high yields. Mechanistic studies indicate that the reaction is enabled by TBADT-mediated hydrogen atom transfer (HAT) photocatalysis. This work is fundamentally different from the previously reported reaction of N,N-dimethylformamide with azobenzenes.
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