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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
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Related Experiment Video

Updated: Jun 7, 2025

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Reticular Chemistry for Enhancing Bioentity Stability and Functional Performance.

Mengchu Feng1, Chunyan Xing1, Yehao Jin1

  • 1Frontiers Science Center for High Energy Material, Advanced Technology Research Institute (Jinan), Key Laboratory of Cluster Science (Ministry of Education), Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Advanced Research Institute of Multidisciplinary Science, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China.

Journal of the American Chemical Society
|November 19, 2024
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Summary
This summary is machine-generated.

Reticular chemistry using metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) stabilizes fragile bioentities. These advanced materials enhance bioentity stability, activity, and applications.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Chemistry

Background:

  • Bioentities like enzymes and cells are often fragile, limiting their stability and performance during storage and application.
  • Reticular chemistry provides porous frameworks for bioentity stabilization and enhancement.

Purpose of the Study:

  • To outline strategies for integrating bioentities with reticular frameworks (MOFs and COFs).
  • To highlight new design ideas for enhancing bioentity performance within these frameworks.
  • To discuss the potential of these biocomposites in broadening bioentity applications.

Main Methods:

  • Integration of bioentities within metal-organic frameworks (MOFs) and covalent organic frameworks (COFs).
  • Utilizing the porous nature of frameworks for efficient loading, mass transfer, and confinement.
  • Tuning biointerfacial interactions and microenvironments for optimized bioentity function.

Main Results:

  • Reticular frameworks significantly enhance bioentity stability and protect against degradation.
  • Frameworks can boost bioentity activity and impart non-native functions.
  • These biocomposites enable synergistic interactions within bioentity systems.

Conclusions:

  • Reticular frameworks offer a powerful platform for developing high-performance bio-based materials.
  • Further research into design, characterization, and application is crucial for advancing this field.
  • Biocomposites hold promise for diverse applications in biotechnology and beyond.