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Hypertriglyceridemia-induced acute pancreatitis in pregnancy associated with CREB3L3 mutation

Chen Gurevitz1, Jeffrey I Mechanick1, Ron Do2

  • 1Metabolism and Lipids Program, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA (Dr Gurevitz, Mechanick, and Rosenson).

Journal of Clinical Lipidology
|November 19, 2024
PubMed

A 40-year-old woman at 35 weeks of gestation presented with abdominal pain and hypertriglyceridemia of above 5000 mg/dL. Following lab tests and imaging studies, she was diagnosed with hypertriglyceridemia-related acute pancreatitis in pregnancy. She was managed with nil per os (NPO), intravenous insulin, and peripheral parenteral nutrition, but her condition further complicated with preeclampsia, and she was induced and delivered at 36 weeks of gestation. Genetic testing revealed a heterozygous variant in the CREB3L3 gene predisposing to severe hypertriglyceridemia. Postpartum lifestyle modifications, including a low-fat diet and routine exercise, significantly improved her lipid profile.

Keywords:
Acute pancreatitisGenetic lipid disordersHypertriglyceridemiaPregnancy complications

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