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Updated: Jun 7, 2025

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy
Published on: September 29, 2017
Association between visceral adipose tissue and glomerular hyperfiltration in adolescents: A cross-sectional study
Yong-Chang Yang1, Jing-Ying Zhao1, Cheng-Guang Zhao1
1Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning Province 110004, China.
Objective:
Glomerular hyperfiltration is an early indicator of obesity-related glomerular disease. However, in adolescents, there are no quantifiable indicators of obesity and glomerular hyperfiltration. This study investigates the association between visceral adipose tissue and glomerular hyperfiltration in adolescents.
Methods:
This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES; 2011-2018), and adolescents aged 12-17 years were included. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) formed the independent variables while estimated glomerular filtration rate (eGFR) acted as the dependent variable. Their association was assessed using unadjusted and multivariate regression analyses, as well as subgroup and interaction analyses.
Results:
Multivariate regression analysis revealed that VAT was positively associated with eGFR and glomerular hyperfiltration among adolescents. The incidence of glomerular hyperfiltration increased by 99 % in boys and 56 % in girls per 100 g of VAT increase. Additionally, VAT and eGFR exhibited a linear relationship in both boys (β = 5.63, p < 0.001) and girls (β = 2.72, p < 0.001).
Conclusions:
In US adolescents aged 12-17 years, VAT was positively correlated with eGFR and glomerular hyperfiltration.
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