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Updated: Jun 7, 2025

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
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Rodent Models for ASD Biomarker Development.

Henry H C Lee1, Mustafa Sahin2

  • 1Rosamund Stone Zander Translational Neuroscience Center, F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Advances in Neurobiology
|November 19, 2024
PubMed
Summary
This summary is machine-generated.

Advances in genetics reveal autism spectrum disorder (ASD) complexity. Rodent models aid biomarker discovery for ASD diagnosis and treatment, despite translational challenges.

Keywords:
Autism spectrum disorderBehavioral assaysBiochemical measuresElectrophysiologyMouse genetic models

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Area of Science:

  • Neuroscience
  • Genetics
  • Biochemistry

Background:

  • Autism spectrum disorder (ASD) etiology is complex, involving molecular biology and genetics.
  • Biochemical, anatomical, and electrophysiological measures show promise as ASD biomarkers.
  • Rodent models are crucial for ASD research but face validity and translational challenges.

Purpose of the Study:

  • To review the history and current state of autism research.
  • To highlight disease-relevant rodent models of ASD.
  • To discuss the development and prospects of ASD biomarkers.

Main Methods:

  • Review of historical autism research.
  • Examination of genetic, molecular biology, and bioinformatics-driven rodent ASD models.
  • Discussion of biomarker development from these models.

Main Results:

  • Prominent examples of rodent ASD models have been identified.
  • These models facilitate quantifiable biomarker development.
  • The potential for ASD biomarker development is discussed.

Conclusions:

  • Rodent models are valuable tools in ASD research.
  • Despite limitations, these models contribute to biomarker discovery.
  • Further research holds promise for improved ASD diagnosis and management through biomarkers.