Neuroimaging Biomarkers in Parkinson's Disease

Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder that affects multiple systems in the body and is characterized by a variety of motor and non-motor (e.g., psychiatric, autonomic) symptoms. As the fastest growing neurological disorder expected to affect over 12 million people globally by 2040 (Dorsey, Bloem JAMA Neurol 75(1):9-10. https://doi.org/10.1001/jamaneurol.2017.3299 . PMID: 29131880, 2018), PD poses an enormous individual and public health burden. Currently, there are no therapies that can slow down the disease progression in PD, and existing therapies are limited to symptomatic treatment. Importantly, people in the prodromal phase who are at high risk of developing PD can now be identified, which makes disease prevention an achievable goal. An in-depth understanding of the pathological processes in PD is crucial for prevention and treatment development. Advanced multimodal neuroimaging techniques provide unique biomarkers that can further our understanding of PD at multiple levels ranging from neurotransmitters to neural networks. These neuroimaging biomarkers also have value in clinical application, for example, in the differential diagnosis of PD. As the field continues to advance, neuroimaging biomarkers are expected to become more specific, more widely accessible, and can be readily incorporated into translational research for treatment development in PD.