Sound innovations for biofabrication and tissue engineering.

Area of Science:

• Biofabrication and Tissue Engineering
• Biotechnology
• Biomedical Engineering

Background:

• Advanced biofabrication techniques create tissue constructs for reconstructive surgery and in vitro disease modeling.
• While many biofabrication methods are reviewed, acoustics-based technologies remain underexplored.
• Acoustic technology publications have surged in the last two decades, indicating significant potential.

Purpose of the Study:

• To review the application of acoustics-based technologies in biofabrication.
• To highlight the advantages of acoustic methods over traditional techniques.
• To discuss how acoustic technologies can enhance organoid functionality and address challenges in tissue engineering.

Main Methods:

• Review of existing literature on acoustics in biofabrication.
• Discussion of acoustic mechanisms for cell assembly.
• Examination of novel acoustic technologies and their integration with traditional methods.

Main Results:

• Acoustics offer unique advantages: noncontact manipulation, biocompatibility, deep tissue penetrability, precision control, high-throughput, and multilayered assembly.
• Acoustic methods can overcome limitations of other biofabrication techniques.
• Integration of novel acoustic technologies with traditional methods provides innovative solutions for organoid development.

Conclusions:

• Acoustics-based biofabrication presents a promising frontier in tissue engineering.
• These technologies have the potential to address fundamental challenges and advance the field.
• Acoustic technologies are poised to play a significant role in future biofabrication applications.