Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

3.5K
Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
3.5K
Facilitated Diffusion01:16

Facilitated Diffusion

316
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
316
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

23.6K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
23.6K
Transport Across the Golgi01:26

Transport Across the Golgi

4.1K
While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
4.1K
Membrane Transporters01:31

Membrane Transporters

10.4K
Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...
10.4K
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

446
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
446

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical interactions govern self-organized ordering in bacterial colonies on surfaces.

Physical biology·2026
Same author

Kinesin-Induced Buckling Reveals the Limits of Microtubule Self-Repair.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Association of peripheral and CSF zinc levels with Parkinson's disease: A systematic review and meta-analysis.

IBRO neuroscience reports·2026
Same author

Alternatively spliced STIM2.3 is an evolutionarily late store-operated Ca2+ entry regulator expressed in brain.

Journal of cell science·2026
Same author

Sigma B regulated motility and chemotaxis in <i>Bacillus cereus</i>.

Microbiology (Reading, England)·2026
Same author

Inferring tree structure with hidden traps from first-passage times.

Physical review. E·2025

Related Experiment Video

Updated: Jun 7, 2025

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature
09:39

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature

Published on: November 18, 2019

5.8K

Vulnerability of transport through evolving spatial networks.

Ali Molavi1, Hossein Hamzehpour1, Reza Shaebani2

  • 1Department of Physics, <a href="https://ror.org/0433abe34">K.N. Toosi University of Technology</a>, Tehran 15875-4416, Iran.

Physical Review. E
|November 20, 2024
PubMed
Summary

Researchers studied blockage vulnerability in evolving spatial networks by blocking central transport hubs. They discovered a self-similar blockage path, enabling prediction of network impenetrability and revealing increased spatial correlations.

More Related Videos

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

995
Trajectory Data Analyses for Pedestrian Space-time Activity Study
16:14

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Published on: February 25, 2013

13.5K

Related Experiment Videos

Last Updated: Jun 7, 2025

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature
09:39

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature

Published on: November 18, 2019

5.8K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

995
Trajectory Data Analyses for Pedestrian Space-time Activity Study
16:14

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Published on: February 25, 2013

13.5K

Area of Science:

  • Network science
  • Complex systems
  • Materials science

Background:

  • Understanding transport resilience in networks like porous media and urban infrastructure is crucial.
  • Spatial networks exhibit vulnerability to blockages impacting robustness and failure.

Purpose of the Study:

  • To investigate the blockage vulnerability of evolving spatial networks.
  • To determine the characteristics of the blockage backbone and predict network impenetrability.

Main Methods:

  • Exhaustive search for central transport hubs on porous lattice structures.
  • Recursive determination and blocking of main hubs until network impenetrability.
  • Analysis of blockage backbone fractal dimension and shortest-path length distribution.

Main Results:

  • The blockage backbone exhibits a self-similar path with a fractal dimension smaller than optimal path crack models.
  • A master curve predicts the onset of network impenetrability based on initial occupation fraction and network size.
  • The blocking process leads to broadening of shortest-path length distribution, indicating increased spatial correlations.

Conclusions:

  • The study provides insights into the self-similar nature of network blockages.
  • A predictive model for network impenetrability is established.
  • Findings are relevant for understanding and managing resilience in various real-world networks.