Anomalous diffusion of active Brownian particles in responsive elastic gels: Nonergodicity, non-Gaussianity, and...

Understanding actual transport mechanisms of self-propelled particles (SPPs) in complex elastic gels-such as in the cell cytoplasm, in in vitro networks of chromatin or of F-actin fibers, or in mucus gels-has far-reaching consequences. Implications beyond biology/biophysics are in engineering and medicine, with a particular focus on microrheology and on targeted drug delivery. Here, we examine via extensive computer simulations the dynamics of SPPs in deformable gellike structures responsive to thermal fluctuations. We treat tracer particles comparable to and larger than the mesh size of the gel. We observe distinct trapping events of active tracers at relatively short times, leading to subdiffusion; it is followed by an escape from meshwork-induced traps due to the flexibility of the network, resulting in superdiffusion. We thus find crossovers between different transport regimes. We also find pronounced nonergodicity in the dynamics of SPPs and non-Gaussianity at intermediate times. The distributions of trapping times of the tracers escaping from "cages" in our quasiperiodic gel often reveal the existence of two distinct timescales in the dynamics. At high activity of the tracers these timescales become comparable. Furthermore, we find that the mean waiting time exhibits a power-law dependence on the activity of SPPs (in terms of their Péclet number). Our results additionally showcase both exponential and nonexponential trapping events at high activities. Extensions of this setup are possible, with the factors such as anisotropy of the particles, different topologies of the gel network, and various interactions between the particles (also of a nonlocal nature) to be considered.