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A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance
Published on: October 19, 2018
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Injectable Hyaluronic Acid-Based Hydrogels for Rapid Endoscopic Submucosal Dissection.
Geng Qin1, Ruonan Wu2, Qianqian Wang1
1Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China.
ACS Biomaterials Science & Engineering
|November 20, 2024
Summary
Injectable hyaluronic acid hydrogels significantly improve endoscopic submucosal dissection (ESD) by enhancing lesion lifting and reducing procedure time. These novel hydrogels offer better wound protection in gastrointestinal treatments.
Area of Science:
- Biomaterials Science
- Gastroenterology
- Surgical Innovation
Background:
- Endoscopic submucosal dissection (ESD) is a standard treatment for early gastrointestinal lesions.
- Current materials used in ESD have limitations including short retention, poor lifting capacity, and diffusion, prolonging procedures and compromising wound protection.
- There is a need for improved materials to enhance ESD efficiency and patient outcomes.
Purpose of the Study:
- To design and develop novel injectable hydrogels based on hyaluronic acid for improved ESD procedures.
- To investigate the structure-property relationships of synthesized hyaluronic acid hydrogels.
- To evaluate the performance of the optimized hydrogel in a preclinical model.
Main Methods:
- Synthesis of oxidized hyaluronic acid (OHA) and hydrazide hyaluronic acid (AHA) derivatives.
- Fabrication and characterization of 16 types of injectable hydrogels.
- In vitro assessment of injection performance, gelation, mechanical properties, and biocompatibility (blood and cell compatibility).
- In vivo evaluation in a porcine ESD model to assess retention time, lifting performance, operation time reduction, and wound adhesion.
Main Results:
- The O1A3 hydrogel demonstrated optimal injection, gelation, and mechanical properties, along with excellent in vitro biocompatibility.
- In the porcine ESD model, O1A3 hydrogel showed superior retention and lifting capacity.
- The O1A3 hydrogel significantly reduced ESD procedure time from 1-2 hours to approximately 10 minutes.
- The hydrogel exhibited beneficial adhesive properties for protecting wounds in the gastrointestinal tract.
Conclusions:
- Injectable hyaluronic acid-based hydrogels, specifically the O1A3 formulation, offer a promising solution for enhancing ESD procedures.
- These hydrogels improve surgical efficiency by reducing operation time and providing effective wound protection.
- The developed hydrogels represent a significant advancement in biomaterials for gastrointestinal surgery.
