Related Experiment Video
Updated: Jun 7, 2025

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine
Published on: July 24, 2018
Caffeine intake is nonlinearly associated with muscle mass in young and middle-aged US adults
Lingling Zhou1, Huanjia Qu1, Jing Wang1
1Metabolic Disease Center, Department of Endocrinology and Metabolism, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China.
Background:
Recent studies have indicated that coffee consumption is inversely correlated with sarcopenia in the elderly population. Data regarding the association between caffeine intake and muscle mass in young adults are scarce.
Objective:
We aimed to investigate how dietary caffeine correlates with muscle mass and sarcopenia in the young and middle-aged people.
Methods:
We performed a cross-sectional study utilizing data from NHANES. Muscle mass was evaluated using DXA and caffeine intake was derived from 24-h dietary recalls. Multivariable regression analysis was adopted to explore association between caffeine and sarcopenia. Restricted cubic spline analysis was conducted to investigate dose-response effect of dietary caffeine on muscle mass. Mediation effect of high-sensitivity C reactive protein was examined by mediation analysis.
Results:
A total of 9116 adults aged from 20 to 59 years old were included. Higher ingestion of caffeine was not associated with sarcopenia. Association between dietary caffeine and muscle mass was found to be W-shaped in males and U-shaped in young females, wherein mediation effect of hs-CRP was not discovered.
Conclusions:
Caffeine consumption is associated with muscle mass in a nonlinear pattern. ASMI peaks at a daily caffeine intake of 1.23 mg/kg in young adults, while 0.64-1.49 mg/kg is recommended for middle-aged men.
More Related Videos
04:54Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
Published on: June 2, 2023
07:33Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
Published on: November 8, 2024
Related Concept Videos
Muscle Stimulation Frequency
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Muscle Recovery and Fatigue
Cause and Effect
Experimental Designs