Different associations of atherogenic index of plasma, triglyceride glucose index, and hemoglobin A1C levels with the risk of coronary artery calcification progression according to established diabetes
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View abstract on PubMed
Summary
This summary is machine-generated.The triglyceride glucose (TyG) index is a strong predictor of coronary artery calcification (CAC) progression in both individuals with and without diabetes. Atherogenic index of plasma (AIP) and hemoglobin A1C (HbA1C) showed varying associations depending on diabetes status.
Area Of Science
- Cardiology
- Endocrinology
- Metabolic Syndrome
Background
- Insulin resistance and hyperglycemia are key risk factors for atherosclerosis.
- Coronary artery calcification (CAC) progression is a significant indicator of cardiovascular risk.
- The differential impact of biomarkers like atherogenic index of plasma (AIP), triglyceride glucose (TyG) index, and hemoglobin A1C (HbA1C) on CAC progression in diabetic versus non-diabetic individuals remains underexplored.
Purpose Of The Study
- To investigate the association between AIP, TyG index, and HbA1C levels with CAC progression in asymptomatic adults.
- To determine if these associations differ between individuals with and without established diabetes.
- To identify which of these biomarkers are independent predictors of CAC progression.
Main Methods
- Analysis of 12,326 asymptomatic Korean adults over a median follow-up of 3.0 years.
- Calculation of AIP and TyG index using lipid and glucose measurements.
- Definition of CAC progression using the square root (SQRT) transformation method (Δ√transformed CACS).
- Logistic regression models adjusted for multiple confounding factors were employed.
Main Results
- CAC progression was more prevalent in individuals with diabetes (46.9%) compared to those without (28.0%).
- AIP was associated with CAC progression only in non-diabetics (OR: 1.04).
- HbA1C was significantly associated with CAC progression only in diabetics (OR: 1.19).
- The TyG index demonstrated a significant association with CAC progression in both non-diabetics (OR: 1.32) and diabetics (OR: 1.33).
Conclusions
- The relationship between AIP, TyG index, HbA1C, and CAC progression is contingent upon diabetes status.
- The TyG index emerges as a robust, independent predictor of CAC progression, regardless of the presence of established diabetes.
- These findings highlight the TyG index's utility in assessing cardiovascular risk across diverse metabolic profiles.
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