Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epistasis Analysis01:09

Epistasis Analysis

4.9K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
4.9K
Epistasis01:39

Epistasis

45.9K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
45.9K
Incomplete Dominance01:43

Incomplete Dominance

21.6K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
21.6K
Dihybrid Crosses01:18

Dihybrid Crosses

74.1K
Overview
74.1K
Law of Segregation01:49

Law of Segregation

64.6K
When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.
64.6K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

329
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
329

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma exosomal HERV-K transcripts are increased in amyotrophic lateral sclerosis.

BMC neuroscience·2026
Same author

STMN2 protein depletion via translation deficits and stress granules in amyotrophic lateral sclerosis.

Brain : a journal of neurology·2026
Same author

Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits.

Nature cardiovascular research·2026
Same author

Single-nucleus multiomic atlas of ALS primary motor cortex nominates neuroprotective WDR49-expressing astrocytes.

Research square·2026
Same author

Fulminant cerebral edema in the setting of acute dengue fever after mechanical thrombectomy in a patient with massive stroke and severe hypoalbuminemia: a case report.

Frontiers in medicine·2026
Same author

CYP2D6 variants in amyotrophic lateral sclerosis: an association study of risk and survival.

Brain : a journal of neurology·2026

Related Experiment Video

Updated: Jun 7, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.7K

Considerations in the search for epistasis.

Marleen Balvert1, Johnathan Cooper-Knock2, Julian Stamp3

  • 1Tilburg University, Tilburg, The Netherlands. m.balvert@tilburguniversity.edu.

Genome Biology
|November 20, 2024
PubMed
Summary

Epistasis, genetic interactions influencing traits, could explain missing heritability but remains elusive. Future research should use known biology and systems to guide the search for these complex genetic effects.

More Related Videos

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
07:55

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

8.0K
Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe
13:22

Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe

Published on: September 13, 2022

1.8K

Related Experiment Videos

Last Updated: Jun 7, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.7K
A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
07:55

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

8.0K
Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe
13:22

Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe

Published on: September 13, 2022

1.8K

Area of Science:

  • Genetics
  • Systems Biology
  • Bioinformatics

Background:

  • Epistasis describes how genetic variations interact, influencing phenotypic outcomes.
  • These interactions are biologically plausible and could explain heritability not accounted for by additive models.
  • Despite potential, identifying epistatic interactions has largely failed to uncover 'missing heritability'.

Purpose of the Study:

  • To identify key challenges hindering the discovery of epistatic interactions.
  • To propose a new strategy for effectively searching for epistasis.
  • To address the gap in understanding complex genetic trait contributions.

Main Methods:

  • Review of current challenges in epistasis detection.
  • Proposal for leveraging idealized systems for genetic studies.
  • Strategy incorporating known biological pathways and prior epistatic findings.

Main Results:

  • Identified significant obstacles in current epistasis research.
  • Proposed a framework to enhance the efficiency and success rate of identifying genetic interactions.
  • Highlighted the need for integrating diverse biological knowledge.

Conclusions:

  • The search for epistasis requires novel approaches beyond traditional methods.
  • Utilizing known biological context and systems is crucial for future discoveries.
  • Addressing these challenges will advance our understanding of genetic architecture and heritability.