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Prognostic Significance of the Controlling Nutritional Status (CONUT) Score in Patients with Muscle-Invasive Bladder Cancer after Radical Cystectomy

  • 0Department of Urology, Health Sciences University Tepecik Training and Research Hospital, Izmir Turkey. meclecuy@hotmail.com.
Urology Journal +

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November 20, 2024

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November 20, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The Controlling Nutritional Status (CONUT) score predicts survival in muscle-invasive bladder cancer patients undergoing radical cystectomy. A high CONUT score indicates poorer cancer-specific and overall survival.

Area Of Science

  • Urology
  • Oncology
  • Nutritional Science

Background

  • Radical cystectomy is a primary treatment for muscle-invasive bladder cancer.
  • Nutritional status is increasingly recognized as a factor influencing cancer outcomes.
  • The Controlling Nutritional Status (CONUT) score assesses nutritional status based on serum albumin, total lymphocyte count, and total cholesterol.

Purpose Of The Study

  • To evaluate the prognostic value of the CONUT score in patients treated with radical cystectomy for muscle-invasive bladder cancer.
  • To determine if the CONUT score impacts cancer-specific survival (CSS) and overall survival (OS).

Main Methods

  • Retrospective analysis of medical records from patients undergoing radical cystectomy for muscle-invasive bladder cancer.
  • Patients were stratified into high CONUT (≥3) and low CONUT (<3) groups based on ROC curve analysis.
  • Comparison of oncological outcomes and survival between the two CONUT groups.

Main Results

  • Patients in the high CONUT group exhibited significantly lower CSS (p < 0.001) and OS (p = 0.024) compared to the low CONUT group.
  • Multivariate analysis identified age (HR: 1.02) and CONUT score (HR: 3.92) as independent predictors of OS.
  • A high CONUT score was strongly associated with increased mortality risk.

Conclusions

  • The CONUT score is an independent predictor of survival in patients with muscle-invasive bladder cancer.
  • Nutritional status, as assessed by the CONUT score, plays a significant role in the prognosis after radical cystectomy.
  • The CONUT score can aid in risk stratification and patient management.