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Updated: Jun 7, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Published on: June 21, 2017

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Synthesis of Rapicone Based on Acyl Ketene-Alkyne Cycloaddition

Erandi Liyanage Perera1, Daesung Lee1

  • 1Department of Chemistry, University of Illinois Chicago, 845 West Taylor Street, Chicago, Illinois 60607, United States.

The Journal of Organic Chemistry
|November 20, 2024
PubMed
Summary

Researchers developed a concise 7-step synthesis for rapicone, utilizing an iron-catalyzed oxidation to create a key ynone intermediate. This efficient method achieves a 9.4% overall yield for the total synthesis of rapicone.

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