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Updated: Jun 17, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Solid State Synthesis of Hyaluronic Acid-Quercetin Conjugate: Sustainable Protocol to Improve the Biological Activity
Valentina Verdoliva1, Giuliana Muzio2, Riccardo Autelli2
1Institute of Crystallography, National Research Council, Caserta, Italy.
Abstract:
Herein, a sustainable solid-state procedure is employed for the synthesis of a water-soluble molecule obtained by linking hyaluronic acid to the hydrophobic quercetin (HA-QCT). The micellar self-aggregation of the developed conjugate suggested its employment as a drug delivery nano-system, considering the numerous biological activities of QCT. Indeed, the spectroscopic characterization (ultraviolet-visible and Fourier transform infrared) ensured that the QCT maintained its chemical integrity. In addition, a cytotoxicity test revealed that HA-QCT can be employed as a biocompatible drug vehicle for pharmacological purposes. A preliminary colorimetric test also confirmed that QCT retained its anti-oxidant activity.
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