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Outcomes Using High KDPI Kidneys in Recipients Over 65 y of Age
Naeem Goussous1, Fransia De Leon1, Karima Alghannam1
1Division of Transplant Surgery, Department of Surgery, University of California Davis, Sacramento, CA.
Transplantation Direct
|November 20, 2024
Summary
Utilizing high kidney donor profile index (KDPI) kidneys for patients aged 65 and older can shorten transplant wait times. This strategy does not compromise graft or patient survival, offering a viable solution to organ shortages.
Area of Science:
- Nephrology
- Transplantation Immunology
- Organ Donation
Background:
- Kidney transplantation improves survival compared to dialysis.
- Organ shortages limit transplantation access.
- High KDPI kidneys are an underutilized resource.
Purpose of the Study:
- To evaluate the outcomes of using high KDPI kidneys in older adults.
- To compare high KDPI (KDPI >85) versus low KDPI (KDPI ≤85) kidney transplants.
- To assess the impact on wait times and survival in patients 65+.
Main Methods:
- Retrospective review of kidney transplants in patients 65+ from 2010-2020.
- Comparison of outcomes between high KDPI and low KDPI kidney recipients.
- Statistical analysis with significance defined as P < 0.05.
Main Results:
- High KDPI kidneys came from older donors but had shorter cold ischemic times.
- No significant difference in graft or patient survival between high and low KDPI groups.
- High KDPI recipients experienced significantly shorter pretransplant wait times.
Conclusions:
- High KDPI kidneys can be safely used in patients 65 and older.
- Accepting high KDPI offers reduced wait times without impacting survival.
- This approach helps address organ shortages in kidney transplantation.
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