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A New Frontier in Targeted Therapies: Harnessing PROTACs and Advanced Delivery Systems

Robert B Kargbo1

  • 1Usona Institute, Fitchburg, Wisconsin 53711-5300, United States.

ACS Medicinal Chemistry Letters
|November 20, 2024
PubMed

Insights

Innovative cancer therapies are emerging to tackle difficult-to-treat mutations like KRAS. Proteolysis Targeting Chimeras (PROTACs) and advanced delivery systems offer new hope against challenging oncology targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Targeting KRAS mutations and other "undruggable" oncogenic drivers remains a significant challenge in cancer therapy.
  • Conventional small-molecule inhibitors have limitations in efficacy and delivery for certain cancer targets.
  • The development of novel therapeutic modalities is crucial for advancing cancer treatment strategies.

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