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Neuron-Specific Gene Family Member 1 is a Potential New Therapeutic Target Associated with Immune Cell Infiltration for Breast Cancer

  • 0Department of Breast Surgery, Affiliated Hospital of Hebei Engineering University, Handan, Hebei, 056000, People's Republic of China.
Breast Cancer (dove Medical Press) +

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November 20, 2024

|

November 20, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Neuron-specific gene family member 1 (NSG1) is highly expressed in early breast cancer (BC) and indicates a good prognosis. NSG1 influences the BC immune microenvironment, suggesting it may be a therapeutic target.

Area Of Science

  • Oncology
  • Molecular Biology
  • Immunology

Background

  • Breast cancer (BC) is a heterogeneous disease with unclear roles for specific genes.
  • Neuron-specific gene family member 1 (NSG1), a transmembrane protein, has been observed in various tumors.
  • The specific function and prognostic significance of NSG1 in BC remain largely unexplored.

Purpose Of The Study

  • To investigate the role of NSG1 in breast cancer (BC) pathogenesis and progression.
  • To evaluate NSG1 as a potential prognostic biomarker for BC patients.
  • To explore the association of NSG1 with the BC immune microenvironment.

Main Methods

  • Analysis of NSG1 mRNA expression and prognostic value using The Cancer Genome Atlas and Gene Expression Omnibus databases.
  • Construction of a clinical risk model based on NSG1 expression.
  • Immunohistochemical analysis of NSG1 protein in a cohort of 192 BC patients.
  • Enrichment analysis to predict NSG1's biological functions.
  • Single-cell analysis to assess NSG1's correlation with the BC immune microenvironment.
  • Kaplan-Meier and Cox regression analyses for prognosis and clinicopathological correlations.

Main Results

  • Neuron-specific gene family member 1 (NSG1) exhibits high expression in early-stage breast cancer (BC).
  • Elevated NSG1 expression correlates with a favorable prognosis in BC patients.
  • NSG1 is implicated in the T-cell receptor complex and associated with CD8 T cells within the BC immune microenvironment.
  • NSG1 may promote M1 polarization of macrophages.

Conclusions

  • Neuron-specific gene family member 1 (NSG1) serves as a promising biomarker for good prognosis in breast cancer (BC).
  • NSG1's association with the BC immune microenvironment highlights its potential as a therapeutic target.
  • Further research into NSG1 could lead to novel treatment strategies for BC.

Keywords:

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