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Generalized type II minocycline-induced pigmentation: A case report
Wumei Zhao1, Haijing Fu1, Tianyi Xu1
1Department of Dermatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, P.R. China.
Abstract:
Minocycline-induced pigmentation is a rare dermatological condition that primarily affects the skin and thyroid gland, oral mucosa, nails, teeth, bones, and sclera leading to grayish-blue pigmentation in these areas. Early identification, discontinuation of the drug, and laser treatment are crucial in managing this condition. We reported a case involving a 72-year-old Chinese woman who developed diffuse blue-brown pigmentation after 1 year of minocycline treatment for pemphigus vulgaris. Histological examination revealed multiple pigment-laden macrophages and free pigment in the dermis at the skin lesions. According to our review of the literatures, the generalized skin involvement made our case very rare in comparison with those previously reported of Chinese patients.
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