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Generalized type II minocycline-induced pigmentation: A case report
Wumei Zhao1, Haijing Fu1, Tianyi Xu1
1Department of Dermatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, P.R. China.
SAGE Open Medical Case Reports
|November 20, 2024
Summary
Minocycline can cause rare grayish-blue skin pigmentation, affecting various body parts. This case highlights a rare, widespread presentation in a Chinese patient, emphasizing early diagnosis and treatment for minocycline-induced pigmentation.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Minocycline-induced pigmentation is a rare adverse drug reaction.
- It typically causes grayish-blue discoloration in skin, oral mucosa, nails, teeth, bones, and sclera.
Observation:
- A 72-year-old Chinese woman presented with diffuse blue-brown skin pigmentation after one year of minocycline therapy for pemphigus vulgaris.
- Histological examination of skin lesions showed pigment-laden macrophages and free pigment in the dermis.
Findings:
- The patient's generalized skin involvement is a rare presentation compared to previously reported cases in Chinese patients.
- This case underscores the potential for widespread minocycline-induced pigmentation.
Implications:
- Early identification and drug cessation are key for managing minocycline-induced pigmentation.
- Laser therapy may be considered for treatment.
- Clinicians should be aware of this rare but significant side effect, especially in patients of Chinese descent receiving long-term minocycline treatment.
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