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Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
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The Micturition Reflex01:26

The Micturition Reflex

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Male Sexual Response: Erection & Ejaculation01:17

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Menopause01:28

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Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
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Updated: May 13, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

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Neuromodulation Improves Stress Urinary Incontinence-Like Deficits in Female Rabbits.

F S Rahman1, Z Yousuf2, F Castelan3,4

  • 1University of Houston Houston TX 77004 USA.

IEEE Open Journal of Engineering in Medicine and Biology
|November 20, 2024
PubMed
Summary
This summary is machine-generated.

Sub-chronic neuromodulation of the bulbospongiosus nerve (BsN) significantly reduced urine leakage in rabbits with stress urinary incontinence (SUI). This bioelectronic treatment improved bladder capacity and urethral closure, offering a potential new therapy for SUI.

Keywords:
Bioelectronicselectrical stimulationneural interfacespelvic floor disorderspelvic innervation

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Area of Science:

  • Urology
  • Neuroscience
  • Bioelectronics

Background:

  • Stress urinary incontinence (SUI) affects a significant portion of the female population.
  • SUI is characterized by involuntary urine leakage during physical exertion.
  • Previous studies indicated acute neuromodulation of the bulbospongiosus nerve (BsN) can enhance bladder function.

Purpose of the Study:

  • To investigate the efficacy of sub-chronic BsN neuromodulation in treating SUI-like symptoms in mature multiparous rabbits.
  • To assess the impact of BsN stimulation on urine leakage and urethral closure pressure.

Main Methods:

  • Sub-chronic neuromodulation of the bulbospongiosus nerve (BsN) was applied for 30 days.
  • Voiding spot assay was used to quantify urine leakage events.
  • Measurements included daily micturition volume, voided volume, voiding efficiency, and leak point pressure.

Main Results:

  • A 40% reduction in urine leakage events was observed after 30 days of BsN stimulation.
  • Daily micturition volume increased by 60%, and voided volume increased 10-fold.
  • Significant improvements in voiding efficiency and leak point pressure were noted compared to controls.

Conclusions:

  • Sub-chronic BsN neuromodulation effectively alleviates SUI-like deficits in multiparous rabbits.
  • The treatment improves key metrics such as bladder capacity and urethral closure.
  • BsN neuromodulation shows promise as a bioelectronic treatment modality for SUI.