Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ziegler–Natta Chain-Growth Polymerization: Overview01:17

Ziegler–Natta Chain-Growth Polymerization: Overview

3.2K
Ziegler–Natta polymerization is another form of addition or chain‐growth polymerization used for synthesizing linear polymers over branched polymers. The catalyst used for polymerization is the Ziegler–Natta catalyst, named after Karl Ziegler and Giulio Natta, who developed it in 1953. This catalyst is an organometallic complex of titanium tetrachloride and triethyl aluminum, with the active form of the catalyst being an alkyl titanium compound. Using the Ziegler–Natta...
3.2K
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

2.3K
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma pTau217 and pTau231 predict progression to dementia in Parkinson's disease: a prospective longitudinal study.

NPJ Parkinson's disease·2026
Same author

<i>GCH1</i> p.Ser80Asn Confers Risk for Parkinson's Disease in East Asian Populations.

medRxiv : the preprint server for health sciences·2026
Same author

<i>In Situ</i> Imaging of Nanorod Adsorption and Assembly at Liquid Surfaces.

ACS nano·2026
Same author

Integration of TSPO PET and fluid biomarkers to assess neuroinflammation in Parkinson's disease.

European journal of nuclear medicine and molecular imaging·2026
Same author

Phytochemical-Loaded Biodegradable Nanoemulsions for Eradication of Fungal Biofilms.

Nanomaterials (Basel, Switzerland)·2026
Same author

A Sensitive Multichannel Fluorescent Polymer Sensor Array for the Detection of Protein Fluctuations in Serum.

Sensors (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jun 7, 2025

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

7.8K

Controlled bioorthogonal catalyst self-assembly and activity using rationally designed polymer scaffolds.

Rui Huang1, Cristina-Maria Hirschbiegel1, David C Luther1

  • 1Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@umass.edu.

Nanoscale
|November 20, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces thermo-responsive polymer nanocatalysts for targeted drug delivery. These engineered catalysts precisely release antibiotics upon heating, effectively eradicating bacterial biofilms with minimal side effects.

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.6K

Related Experiment Videos

Last Updated: Jun 7, 2025

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

7.8K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.6K

Area of Science:

  • Polymer Chemistry
  • Nanotechnology
  • Catalysis
  • Drug Delivery
  • Bioorthogonal Chemistry

Background:

  • Polymer-based nanocatalysts offer versatile platforms for advanced drug delivery.
  • Bioorthogonal transition metal catalysts (TMCs) integrated into polymers enable localized therapeutic agent production.
  • Supramolecular interactions within polymers significantly influence nanocatalyst performance.

Purpose of the Study:

  • To co-engineer polymer structures and catalyst encapsulation for controlled supramolecular interactions.
  • To develop thermo-responsive nanocatalysts with precise thermal activation.
  • To demonstrate in situ antibiotic release and bacterial biofilm eradication.

Main Methods:

  • Designing host polymer architectures for tailored supramolecular interactions.
  • Encapsulating bioorthogonal transition metal catalysts within the polymer matrix.
  • Characterizing thermo-responsive behavior and catalytic activity at the nanoscale.

Main Results:

  • Successfully engineered thermo-responsive nanocatalysts with a 6 °C activation resolution.
  • Demonstrated thermal activation of pro-antibiotic deprotection triggered by temperature changes.
  • Achieved external control over bacterial biofilm eradication using the developed nanocatalysts.

Conclusions:

  • Co-engineering polymer structure and catalyst encapsulation precisely controls nanoenvironment supramolecular interactions.
  • Thermo-responsive nanocatalysts offer a promising strategy for targeted drug delivery and biofilm control.
  • This approach minimizes off-target effects by enabling localized therapeutic agent release.