Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The DNA Helix01:16

The DNA Helix

Overview
The DNA Helix01:16

The DNA Helix

Overview
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cooperativity, entropy, and effective concentration in DNA origami self-replication.

Science advances·2026
Same author

A tunable autonomous RNA-fueled micro-engine.

Nature communications·2026
Same author

Blunt-force assembly of programmable DNA architectures using π-π stacking.

Nature communications·2026
Same author

Dynamic Control of DNA Origami Self-Assembly by Transcriptional Modules.

Journal of the American Chemical Society·2026
Same author

DNA Glass: Encasing Diffraction-Quality, Mesoporous DNA Crystals in Architected Silica.

Angewandte Chemie (International ed. in English)·2025
Same author

Control and synchronization of rapid nanoscale DNA heat engine by local heating.

Science advances·2025
Same journal

Cell Membrane-Engineered FePDA Nanoparticles Integrate Ferroptosis and Antitumor Immunity.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Finding the Perfect Match: Investigation of 1,2-Diketone-Based Materials for Use as Cathode Active Material in Rechargeable Magnesium Batteries.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Stabilization of Cu Species in UiO-66 Metal-Organic Framework for CO<sub>2</sub>-to-Methanol: Insights From Operando X-ray and Electron Microscopy Studies.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

BODIPY Photocage-Based Injectable Hydrogel for Light-Controlled Nanoparticle Release.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Multifunctional Nanodiamond Conjugate With a Tumor-Specific EGFR-Targeting Peptide and Photoactivated CO Release for Improved Therapeutic Efficacy in Head and Neck Cancers.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Multifunctional Self-Bonding Biocomposites Enabled by Uniform Dispersion of Carbon Nanotube via In Situ Lignin and Multiple Noncovalent Bonds.

Small (Weinheim an der Bergstrasse, Germany)·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.6K

Silver(I)-Mediated 2D DNA Nanostructures.

Simon Vecchioni1,2, Rainbow Lo3,4, Qiuyan Huang2

  • 1Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|November 20, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed new 2D DNA nanostructures using silver ions (Ag+) for programmable self-assembly. This innovation allows precise metal integration, paving the way for advanced DNA nanoelectronics and functional materials.

Keywords:
Ag+DNA nanotechnologycytosineguanine tetraplexnanomaterials

More Related Videos

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.4K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.5K

Related Experiment Videos

Last Updated: Jun 9, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.6K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.4K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.5K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biochemistry

Background:

  • Structural DNA nanotechnology allows nanoscale self-organization but has limited inorganic and electrical functionality.
  • Nucleic acid metallics enable site-specific metal ion incorporation into DNA for precise functionalization.

Purpose of the Study:

  • To describe a new class of 2D DNA nanostructures utilizing a silver ion (Ag+)-mediated cytosine base pair for self-assembly.
  • To demonstrate programmable assembly of Ag+-functionalized DNA into arrays, rings, and co-assembly with guanine tetraplexes (G4).

Main Methods:

  • Utilized the cytosine-Ag+-cytosine (dC:Ag+:dC) base pair as a chemical trigger for DNA self-assembly.
  • Assembled 2D DNA nanostructures and co-assembled them with guanine tetraplexes (G4).
  • Embedded various nanowires within the 2D DNA lattices at tunable spacings.

Main Results:

  • Demonstrated programmable self-assembly of Ag+-functionalized DNA into large arrays and rings.
  • Successfully co-assembled DNA nanostructures with G4 structures.
  • Assembled 2D DNA lattices with embedded nanowires at controllable distances.

Conclusions:

  • Established a foundation for developing self-assembled, metalated DNA nanostructures.
  • Highlighted the potential for high-precision DNA nanoelectronics with nanometer pitch control.
  • Showcased the versatility of Ag+-mediated DNA assembly for creating complex nanostructures.