Electrocardiographic and biochemical predictors of left ventricular remodeling early after ST-segment elevation...

Area of Science:

• Cardiology
• Medical Diagnostics
• Biomarkers

Background:

• Left ventricular ejection fraction (LVEF) is a critical indicator of cardiac function post-ST-elevation myocardial infarction (STEMI).
• Predicting low to mid-range LVEF early is crucial for managing STEMI patients and preventing adverse cardiac remodeling.
• Baseline electrocardiography (ECG) and standard laboratory tests offer accessible tools for early risk assessment.

Purpose of the Study:

• To identify baseline predictors of low to mid-range LVEF at one-month follow-up in STEMI patients.
• To evaluate the utility of standard 12-lead ECG and routine laboratory tests in assessing post-STEMI cardiac function.
• To establish parameters for early risk stratification in STEMI survivors.

Main Methods:

• Retrospective cross-sectional study involving 130 STEMI patients.
• Multivariate linear regression analysis to correlate baseline ECG and clinical/laboratory parameters with 1-month LVEF.
• Analysis included parameters such as age, peak CK-MB, QTc interval, STE amount, V5-6 RWPT, and aVR RWPT.

Main Results:

• Mean LVEF at 1-month follow-up was 51.8 ± 8.7%.
• Significant negative correlations were observed between LVEF and age, peak CK-MB, QTc interval, STE amount, V5-6 RWPT, and aVR RWPT.
• Baseline aVR R wave peak time (RWPT) and peak CK-MB level were identified as the most significant predictors of low-to-mid-range LVEF (<50%).

Conclusions:

• Baseline aVR RWPT and peak CK-MB levels are associated with reduced LVEF at one month post-STEMI.
• These easily obtainable parameters can aid in the risk stratification of STEMI patients.
• Utilizing aVR RWPT and peak CK-MB may help identify patients at risk for adverse left ventricular remodeling.