Morphine enhances gastric mucus synthesis in rats

The effect of morphine on gastric mucus synthesis was studied in conscious rats, using the method of staining mucus with alcian blue then destaining it with magnesium chloride. It was found that morphine significantly enhanced gastric mucus synthesis, as did fentanyl, a non-histamine-liberating opioid. The effects of the opioids on mucus synthesis were significantly attenuated by pretreatment with naloxone 8 mg/kg or cimetidine 100 mg/kg. Cimetidine itself significantly suppressed gastric mucus production in saline-treated rats. These findings suggest that the increased gastric mucus synthesis caused by morphine is due to activation of opiate receptors and not to histamine release. It appears that cimetidine may counteract rather than block the receptor effects of the opioids by a direct action on the mucus-secreting glands.