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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
Published on: June 16, 2017
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Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics
Alyssa C Parker1,2, Joseph C Van Amburg1,2, J Brett Heimlich3
1Program in Human Genetics, Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN.
Blood
|November 20, 2024
Abstract:
We have developed a cost-effective DNA methylation sequencing assay to improve monitoring of clonal hematopoiesis. By inferring cell-type proportions, this method enhances interpretation of clonal trajectories compared with interpretation based on variant allele fraction only.
