Related Experiment Video
Updated: Jun 7, 2025

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System
Published on: December 21, 2016
Association between wildfire-related PM2.5 and epigenetic aging: A twin and family study in Australia
Yao Wu1, Rongbin Xu1, Shanshan Li1
1Climate, Air Quality Research (CARE) Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, VIC, Australia.
Abstract:
Wildfire-related PM2.5 has been associated with various adverse health outcomes, but its association with epigenetic aging remains unclear. This study examined the association between wildfire-related PM2.5 exposure and epigenetic aging using DNA methylation data from a twin and family study. With a within-sibship analysis, we found that each 1 µg/m3 increase in annual wildfire-related PM2.5 was associated with a 0.25-year (95 % CI: 0.04, 0.47) increase in GrimAge1 acceleration and a 0.36-year (95 % CI: 0.12, 0.59) increase in GrimAge2 acceleration. Subgroup analyses found that participants aged ≥ 60 years, those with a history of current or former smoking and alcohol consumption, and those living in rural regions exhibited more pronounced epigenetic age acceleration. These findings suggest that wildfire smoke could accelerate biological aging, particularly in vulnerable populations, posing a significant challenge to healthy aging.
More Related Videos
11:31Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
Published on: November 30, 2015
14:56Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Related Concept Videos
Gene-Environment Interactions
Epigenetic Regulation
X-chromosome...
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Meiosis I
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...