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Related Experiment Videos

Composition of the pelvic nerve.

W G Dail, N Minorsky

    Experimental Neurology
    |April 1, 1986
    PubMed
    Summary

    Surgical interruption of the pelvic nerve increased vasoactive intestinal polypeptide in rat pelvic ganglia. This indicates a population of these neurons send axons proximally within the pelvic nerve.

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    Area of Science:

    • Neuroscience
    • Autonomic Nervous System Research
    • Peptide Signaling

    Background:

    • Vasoactive intestinal polypeptide (VIP) is a key neurotransmitter in the autonomic nervous system.
    • The precise axonal projections of VIP-containing neurons in the major pelvic ganglion are not fully understood.

    Purpose of the Study:

    • To investigate the origin and projection pathways of vasoactive intestinal polypeptide (VIP)-containing neurons within the rat major pelvic ganglion.
    • To determine if VIP-immunoreactive fibers in the pelvic nerve originate from the major pelvic ganglion.

    Main Methods:

    • Surgical transection of the pelvic nerve and parasympathetic fibers at different anatomical locations in rats.
    • Immunohistochemical staining to detect vasoactive intestinal polypeptide (VIP) immunoreactivity.
    • Retrograde neuronal tracing using dye application to the cut nerve.

    Main Results:

    • Surgical interruption of the pelvic nerve led to increased VIP immunoreactivity in the major pelvic ganglion.
    • Two distinct changes were observed: appearance of varicose/smooth fibers in the neuropil and increased VIP reactivity in some ganglion cells.
    • Transection of preganglionic fibers closer to their spinal origin did not affect VIP immunoreactivity.
    • Retrograde labeling confirmed that ganglion cells project axons distally in the pelvic nerve.

    Conclusions:

    • A subpopulation of VIP-containing neurons resides within the major pelvic ganglion.
    • These VIP-neurons project their axons proximally within the pelvic nerve.
    • The pelvic nerve contains efferent VIP-ergic fibers originating from the major pelvic ganglion.

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