Bionic cell wall models: Utilizing TEMPO-oxidized cellulose nanofibers for fucoxanthin delivery systems

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Nutraceuticals

Background:

• Fucoxanthin (FX) possesses significant biological benefits but is limited by poor oral bioavailability.
• Developing effective delivery systems is crucial for maximizing FX's therapeutic potential.

Purpose of the Study:

• To engineer a novel bionic cell wall model for enhanced fucoxanthin delivery.
• To improve the stability and controlled release of liposomal fucoxanthin.

Main Methods:

• Fabrication of a bionic cell wall using TEMPO-oxidized cellulose.
• Encapsulation of fucoxanthin within liposomes.
• Evaluation of liposome stability and FX release under simulated gastric and intestinal conditions.

Main Results:

• The TEMPO-oxidized cellulose bionic cell wall significantly enhanced liposome stability in acidic environments.
• The bionic cell wall demonstrated pH-responsive release, dispersing and releasing fucoxanthin in simulated intestinal fluid.
• The protective coating prevented degradation of both liposomes and fucoxanthin in simulated gastric conditions.

Conclusions:

• Cellulose-based bionic cell walls show great promise for stabilizing and delivering bioactive compounds like fucoxanthin.
• This approach offers a versatile platform for designing advanced carriers for functional ingredients.
• The developed system addresses the bioavailability challenges of fucoxanthin, paving the way for its improved utilization.