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Pullulan dialdehyde cross-linked dual-action adhesive with high adhesion to lung tissue and the capability of pH-responsive drug release

  • 0School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.
Carbohydrate Polymers +

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November 20, 2024

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November 20, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Researchers developed a novel lung adhesive from fish skin gelatin and pullulan dialdehyde to seal air leaks and deliver chemotherapy drugs. This dual-action adhesive shows promise in reducing post-surgery complications in lung cancer patients.

Area Of Science

  • Biomaterials Science
  • Surgical Innovation
  • Drug Delivery Systems

Background

  • Thoracoscopic lung cancer surgery faces challenges like persistent air leaks and cancer recurrence.
  • Existing treatments often lack targeted drug delivery and effective sealing capabilities.

Purpose Of The Study

  • To develop an in-situ, pH-responsive adhesive for lung cancer surgery.
  • To create a dual-action system for sealing air leaks and releasing anticancer drugs.

Main Methods

  • Formulation of a lung adhesive using hydrophobically modified cold-water fish skin gelatin (hm-CFG) and pullulan dialdehyde (PDA).
  • Incorporation of succinic dihydrazide-modified doxorubicin (SDH-DOX) for pH-responsive drug release.
  • Optimization of the adhesive formulation (9C10-CFG/PDA) and evaluation of its mechanical properties and sealing efficacy in a rat pneumothorax model.

Main Results

  • The optimal 9C10-CFG/PDA adhesive demonstrated excellent cohesive strength, mechanical flexibility (strain >170%), and interfacial adhesion.
  • The adhesive exhibited a burst strength nearly six times higher than commercial fibrin sealant.
  • In vivo testing showed favorable wound-sealing properties and restored rat behavior.
  • The SDH-DOX@Adhesive formulation provided a more gradual, pH-responsive drug release compared to unmodified doxorubicin.

Conclusions

  • The developed dual-action adhesive effectively seals lung air leaks and delivers anticancer drugs in a pH-responsive manner.
  • This innovative biomaterial holds potential for mitigating post-surgical complications and improving outcomes in lung cancer treatment.

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