Chromatography-free synthesis of 2^A,2^B-disulfonated β-cyclodextrin for regiospecific di-substitution

Cyclodextrins and their derivatives have extensive applications across pharmaceuticals, cosmetics, and the food industry due to their unique hydrophobic cavities. While monosubstituted cyclodextrin derivatives have established synthesis protocols, di-substituted derivatives pose significant challenges, including low yields and complex purification processes. This study presents a novel methodology for synthesizing di-substituted cyclodextrin derivatives, achieving a 33 % yield without relying on chromatographic techniques. This new approach streamlines the synthesis and purification process, making it more practical for large-scale applications and enhancing the utility of cyclodextrin derivatives in various industries.