[Benzylidene-5 pyrrolones, furanones and thiophenones. 2. Quantitative structure-activity relationship]

Quantitative structure-activity relationships (QSAR) have been derived for twenty two 5-benzylidene furanones, pyrrolones and thiophenones having antifungal activity against Candida albicans. The correlation with the parabolic (Hansch) or bilinear (McFarland-Kubinyi) models are superior to those with the linear models (Free-Wilson or Fujita-Ban), while no significant differences exist between the parabolic and bilinear models. Lipophilicity was necessary for good in vitro activity of these compounds.