Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cartilage targeted grape skin-derived extracellular vesicles ameliorate osteoarthritis by attenuating chondrocyte senescence.

Journal of nanobiotechnology·2026

Same author

One-step microwave-assisted synthesis of nitrogen-doped carbon quantum dots for highly sensitive and selective fluorescence detection of mercury (II) ion in food.

Food chemistry: X·2026

Same author

Design and application of a FA-based molecularly imprinted sensor for screening anti-Fusariumoxysporum substances from Lanzhou lily endophytes.

Bioelectrochemistry (Amsterdam, Netherlands)·2026

Same author

Nomogram prediction model for pain recurrence in patients with trigeminal neuralgia after microvascular decompression.

Neurosurgical review·2026

Same author

Safety and efficacy of decompressive craniectomy versus standard craniotomy for large acute epidural haematoma with tentorial herniation in China (PREDICT-AEDH): a nationwide, multicentre, open-label, parallel-group, randomised controlled trial.

The Lancet. Neurology·2026

Same author

Electronic modulation of Fe-N<sub>4</sub> sites by second-shell sulfur for enhanced oxygen reduction electrocatalysis.

Chemical communications (Cambridge, England)·2026

Same journal

Coral-inspired immunoreprogramming scaffold reverses the "immune-freeze" microenvironment to promote bone regeneration in steroid-induced osteonecrosis of the femoral head.

Bone research·2026

Same journal

Angiogenin mediates cell-cell fusion as a mitochondrial RNA processing enzyme.

Bone research·2026

Same journal

Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization, misaligned mineral crystals, and altered osteoblast differentiation.

Bone research·2026

Same journal

An ITGA11 expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cells.

Bone research·2026

Same journal

JMJD3-driven epigenetic reprogramming of p16<sup>INK4a</sup>-positive cells promotes tendon regeneration.

Bone research·2026

Same journal

Novel therapeutic strategies for osteoarthritis: from mechanistic insights to precision medicine.

Bone research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 7, 2025

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

Engineering bone/cartilage organoids: strategy, progress, and application.

Long Bai^1,2,3,4, Dongyang Zhou^1,2,3, Guangfeng Li⁵

¹Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

|November 20, 2024

Summary

This summary is machine-generated.

Bone/cartilage organoids, miniature in vitro tissues, offer new ways to study bone biology and disease. Advances in construction and applications promise significant impacts on regenerative medicine and patient-specific treatments.

More Related Videos

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

Related Experiment Videos

Last Updated: Jun 7, 2025

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

Area of Science:

Biotechnology
Regenerative Medicine
Tissue Engineering

Background:

Bone/cartilage organoids are miniature in vitro tissues enabling study of complex biological processes.
Their development is crucial for advancing fundamental and translational bone biology research.
Organoids provide a controlled environment to investigate cellular interactions and disease pathology.

Purpose of the Study:

To provide a comprehensive overview of bone/cartilage organoid construction strategies.
To review recent research progress and potential applications of these organoids.
To discuss challenges and propose future directions in the field.

Main Methods:

Review of current literature on bone/cartilage organoid development.
Analysis of cell selection, matrix gels, and construction techniques.
Exploration of emerging technologies like bioprinting and AI.

Main Results:

Detailed strategies for constructing bone/cartilage organoids are presented.
The review highlights organoids' utility in reconstruction, disease modeling, and drug screening.
Potential solutions to current challenges, including bioprinting and AI, are discussed.

Conclusions:

Bone/cartilage organoids hold significant potential for understanding and treating bone/cartilage diseases.
Standardization and technological advancements are key to realizing their full potential.
These organoids are poised to drive patient-specific therapies and advance regenerative medicine.