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Related Experiment Video

Updated: Jun 7, 2025

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

Quantitative study on objective indicators for assessing motion sickness susceptibility based on Vestibulo-Ocular

Yue Li¹, Liwen Pan², Muchen Liu¹

¹School of Medical Imaging, Xuzhou Medical University, Xuzhou, 221004, China.

Scientific Reports

|November 20, 2024

Summary

Motion sickness (MS) diagnosis can be improved using objective nystagmus measures. Vestibulo-ocular reflex parameters like slow-phase velocity and time constants correlate with MS susceptibility, enabling quantitative clinical assessment.

Keywords:

Cupula time constant K-Means clustering analysis Motion sickness susceptibility Nystagmus slow-phase velocity Velocity storage time constant

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Last Updated: Jun 7, 2025

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

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Published on: December 14, 2014

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

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Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

Published on: May 23, 2013

Area of Science:

Neuroscience
Ophthalmology
Vestibular System Research

Background:

Motion sickness (MS) is a common condition triggered by acceleration stimuli, arising from sensory conflicts.
Current MS diagnosis relies on subjective questionnaires, lacking objective, quantifiable indicators.
The vestibular system's role in sensing acceleration makes it central to MS pathogenesis.

Purpose of the Study:

To identify objective indicators for evaluating motion sickness susceptibility.
To correlate vestibulo-ocular reflex (VOR) parameters with subjective MS scores.
To develop a quantitative framework for clinical MS diagnosis.

Main Methods:

Rotating chair stop experiments were performed on 65 volunteers to measure nystagmus slow-phase velocity and time constants.
Volunteers completed detailed motion sickness questionnaires to assess susceptibility.
Correlation and K-Means clustering analyses were used to link VOR parameters with MS scores.

Main Results:

Significant positive correlations were found between maximal nystagmus slow-phase velocity, cupula time constant, velocity storage time constant, and MS questionnaire scores.
Nystagmus parameters demonstrated significant correlation with subjective MS susceptibility.
K-Means clustering successfully categorized MS susceptibility into four levels based on nystagmus parameters.

Conclusions:

Nystagmus slow-phase velocity and related time constants serve as objective indicators for assessing MS susceptibility.
These objective measures provide a quantitative basis for clinical MS diagnosis.
The study offers a novel, objective approach to evaluating and classifying motion sickness.