Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissues01:18

Tissues

70.2K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
70.2K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

3.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K
Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

29.2K
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
29.2K
Tissues01:25

Tissues

63.6K
Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
63.6K
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

6.8K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
6.8K
Bone Cells and Tissue01:30

Bone Cells and Tissue

12.5K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
12.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Risk Rhabdomyosarcomas Feature a Convergent Cell State.

Cancer research·2026
Same author

Inherited human TFIIIA deficiency disrupts T cell development.

medRxiv : the preprint server for health sciences·2026
Same author

Human embryonic stem cell-derived dopaminergic cells for Parkinson's disease: a phase 1/2 open-label trial.

Nature medicine·2026
Same author

Heterogeneity and dynamics of DENV-specific CD8 + T cells in dengue infection.

Nature communications·2026
Same author

A Hormone Cell Atlas maps the human endocrine system at cellular resolution.

Science (New York, N.Y.)·2026
Same author

Editorial: Silent But Detectable-High-Throughput Proteomics to Identify Clinically Significant Liver Disease.

Alimentary pharmacology & therapeutics·2026

Related Experiment Video

Updated: May 2, 2026

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

6.7K

A spatial human thymus cell atlas mapped to a continuous tissue axis.

Nadav Yayon1,2,3, Veronika R Kedlian1,3, Lena Boehme4

  • 1Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK.

Nature
|November 20, 2024
PubMed
Summary

Researchers mapped human thymus development using a new framework, revealing early establishment of immune cell pathways and niches by the second trimester. This work enhances understanding of T cell development and offers a toolkit for tissue analysis.

More Related Videos

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

17.0K
Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
03:31

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

Published on: October 4, 2024

1.4K

Related Experiment Videos

Last Updated: May 2, 2026

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

6.7K
Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

17.0K
Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
03:31

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

Published on: October 4, 2024

1.4K

Area of Science:

  • Developmental immunology
  • Tissue morphology
  • Single-cell biology

Background:

  • T cell development occurs in the thymus, a process active from fetal stages through adolescence.
  • Understanding the thymus's microanatomy is crucial for studying T cell maturation and selection.

Purpose of the Study:

  • To map the microanatomical structures supporting T cell development in early human fetal and postnatal stages.
  • To analyze the spatial organization of thymic components and thymocyte trajectories.

Main Methods:

  • Established a quantitative morphological framework (Cortico-Medullary Axis) for thymus analysis.
  • Applied the framework to multimodal single-cell atlas, spatial transcriptomics, and multiplex imaging data.
  • Developed a toolkit (TissueTag) for cross-platform imaging data analysis and OrganAxis construction.

Main Results:

  • Demonstrated establishment of the lobular cytokine network, thymocyte trajectories, and thymic epithelial cell distributions by the second trimester of fetal development.
  • Identified progenitor niches for thymic epithelial cells and subtypes associated with Hassall's corpuscles.
  • Revealed differential timing of medullary entry for CD4 and CD8 T cell lineages.

Conclusions:

  • The study provides a detailed map of early human thymus development and T lymphocyte maturation.
  • Findings offer insights into the establishment of immune cell niches and developmental trajectories.
  • The developed toolkit (TissueTag) facilitates analysis of complex tissue architectures across various datasets.