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Clinicopathological Significance of Extranodal Adipose Tissue Invasion in Metastatic Lymph Nodes in Patients With Prostate Cancer

  • 0Morphological Analysis Laboratory, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan.
The Prostate +

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November 20, 2024

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November 20, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Prostate cancer patients with higher leptin and lower adiponectin levels in the blood are more likely to have lymph node (LN) metastasis. Adipokines may predict LN metastasis and cancer progression.

Area Of Science

  • Oncology
  • Pathology
  • Endocrinology

Background

  • Lymph node (LN) metastasis is a critical prognostic indicator in prostate cancer.
  • Understanding the role of the metastatic microenvironment, particularly adipocytes, is vital for developing new therapies.
  • This study investigates the clinical significance of extranodal adipose tissue invasion and adipokine levels in prostate cancer with LN metastasis.

Purpose Of The Study

  • To determine the clinicopathological significance of extranodal adipose tissue invasion in metastatic LNs.
  • To evaluate the association between preoperative adipokine (adiponectin and leptin) concentrations and clinicopathological features in prostate cancer patients with LN metastasis.

Main Methods

  • Histopathological examination of 66 specimens from 46 prostate cancer patients, focusing on primary and metastatic nodes.
  • Analysis of preoperative blood samples from 56 patients to measure adiponectin and leptin concentrations.
  • Sub-analysis to correlate adipokine levels with clinical and pathological findings, including LN metastasis and recurrence.

Main Results

  • Metastatic LN count correlated with adipose tissue invasion and lymphovascular invasion.
  • Lower preoperative adiponectin levels were associated with positive surgical margins and extraprostatic extension.
  • Significantly lower adiponectin and higher leptin concentrations were observed in patients with LN metastasis compared to those without.
  • In patients with LN metastasis, lower adiponectin levels predicted biochemical recurrence.

Conclusions

  • This study highlights the histopathological characteristics of prostate cancer with LN metastases.
  • Preoperative adiponectin concentration is a significant predictor of pathological features and LN metastasis in prostate cancer.
  • Adipokines and adipose tissue may play a crucial role in the progression of both primary and metastatic prostate cancer.

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