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Correlation between PDGF-BB and M1-type macrophage in inflammatory bowel disease: a case-control study.
Zhiyun Fang1, Siwen Qu1, Xia Ji1
1The Second Hospital of Jiaxing, Jiaxing, 314000, China.
BMC Gastroenterology
|November 20, 2024
Summary
Platelet-derived growth factor-BB (PDGF-BB) and M1 macrophages are elevated in active inflammatory bowel disease (IBD). These markers show diagnostic potential for active IBD, aiding in disease management.
Area of Science:
- Gastroenterology
- Immunology
- Biomarker Discovery
Background:
- Inflammatory bowel disease (IBD) involves macrophages in pathogenesis.
- Platelet-derived growth factor-BB (PDGF-BB) aids vascular repair during inflammation.
Purpose of the Study:
- To investigate the role of PDGF-BB and M1 macrophages in IBD.
- To evaluate their diagnostic value for active IBD.
Main Methods:
- Enzyme-linked immunosorbent assays and immunohistochemistry used for 30 CD and 30 UC patients.
- Logistic regression and ROC curve analysis for diagnostic value assessment.
- Spearman correlation analysis for evaluating associations.
Main Results:
- Elevated serum and colonic PDGF-BB and M1 macrophage markers (CD86, CXCL9) in active IBD patients compared to remission and controls.
- Positive correlation between CD86, CXCL9, and PDGF-BB levels.
- CD86 and PDGF-BB in colonic mucosa are independent risk factors for active IBD.
Conclusions:
- PDGF-BB is associated with M1 macrophages in IBD.
- PDGF-BB and M1 macrophage markers show potential for diagnosing active IBD.
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