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Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

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Telomeres: an organized string linking plants and mammals.

Edison Di Pietro¹, Romina Burla^1,2, Mattia La Torre¹

¹Department of Biology and Biotechnologies "Charles Darwin", Sapienza, University of Rome, Rome, Italy.

|November 21, 2024

Summary

Telomeres, crucial for cell stemness and aging, share common traits in plants (Arabidopsis thaliana) and mammals (mice, humans). Studying these similarities, including TTAGGG repeats and protein protection, offers insights into aging and lifespan.

Keywords:

Aging Epigenetics Humans Lifespan Mice Niche Plants Shelterin Stem cells Telomeres

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Area of Science:

Comparative biology
Molecular biology
Genetics

Background:

Telomeres critically influence cellular stemness, organismal aging, and lifespan.
Understanding telomere biology is key to addressing age-related decline.
Cross-species comparisons can reveal conserved mechanisms.

Purpose of the Study:

To investigate conserved features of telomeres across diverse species, including plants and mammals.
To explore the relationship between telomere biology, cell stemness, and aging.
To highlight the impact of environmental niches on stemness.

Main Methods:

Comparative analysis of telomere structure and function.
Examination of telomere-associated proteins.
Discussion of stemness regulation in different organisms.

Main Results:

Identified conserved traits in telomeres of Arabidopsis thaliana, mice, and humans.
Common features include TTAGGG repeat composition and specialized protein protection.
Observed convergence in plant and mammalian cell stemness regulation, influenced by niches.

Conclusions:

Telomere structure and function exhibit fundamental similarities across kingdoms.
Niche-specific factors play a significant role in regulating cell stemness.
A comparative approach integrating plant and mammalian studies enhances understanding of aging and lifespan determinants.