Related Experiment Video
Updated: Jun 7, 2025
Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography
Published on: January 17, 2025
Characterization of the craniofacial abnormalities of the homozygous G608G progeria mouse model
Indeevar Beeram1, Maria Belen Cubria1, Pramod Kamalapathy1
1Musculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Introduction:
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by premature aging, impacting multiple organ systems, including cardiovascular, musculoskeletal, and integumentary. Significant abnormalities in a transgenic mouse model (homozygous G608G mutation), specifically targeting the development of skull and facial bone indices through high-resolution CT scanning and cephalometric analysis.
Methods:
Key measurements include bone thickness, skull volume, and cranial suture integrity. Bone volume increased significantly in HGPS mice by 8 months of age compared to wildtype mice.
Results:
Cortical thickness showed a trend toward increased values in HGPS mice. Cranial metrics revealed distinct differences.
Discussion:
HGPS mice exhibited smaller internasal width, interzygomatic distance, and palatine length compared to WT mice over time.
